Peter M van der Kraan Selected Research

2- (5- benzo(1,3)dioxol- 5- yl- 2- tert- butyl- 3H- imidazol- 4- yl)- 6- methylpyridine hydrochloride

1/2022	Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis.
1/2022	Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes.

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Peter M van der Kraan Research Topics

Disease

24	Osteoarthritis 01/2022 - 07/2002
22	Arthritis (Polyarthritis) 11/2021 - 12/2007
16	Inflammation (Inflammations) 01/2022 - 12/2007
12	Experimental Arthritis 01/2022 - 09/2015
8	Rheumatoid Arthritis 01/2022 - 03/2016
6	Osteophyte 10/2016 - 07/2002
5	Hypertrophy 01/2022 - 01/2012
4	Fibrosis (Cirrhosis) 01/2022 - 01/2006
3	Disease Progression 01/2022 - 10/2017
3	Joint Diseases (Joint Disease) 05/2018 - 06/2013
2	Systemic Scleroderma (Systemic Sclerosis) 11/2021 - 08/2018
2	Pain (Aches) 01/2020 - 10/2017
2	Synovitis 01/2020 - 12/2003
2	Osteitis 01/2019 - 10/2016
2	Autoimmune Diseases (Autoimmune Disease) 01/2017 - 01/2017
1	Acute Pain 01/2020
1	Hyperalgesia 01/2020
1	Hypercholesterolemia 11/2019
1	Bone Resorption 01/2019
1	Edema (Dropsy) 01/2018
1	Stress Fractures (Stress Fracture) 11/2017
1	Encephalomyelitis (Myeloencephalitis) 01/2017
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2017
1	Necrosis 12/2016
1	Atherosclerosis 01/2016

Drug/Important Bio-Agent (IBA)

11	CytokinesIBA 01/2020 - 04/2004
8	Transforming Growth Factor beta (TGF-beta)IBA 01/2014 - 07/2002
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2009
5	Messenger RNA (mRNA)IBA 01/2021 - 01/2007
5	AntigensIBA 12/2020 - 01/2017
5	AlarminsIBA 01/2020 - 01/2016
4	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 01/2007
4	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2019 - 10/2016
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 05/2018
3	Interleukin-22 (IL-22)IBA 01/2021 - 01/2018
3	oxidized low density lipoproteinIBA 11/2019 - 11/2013
3	Proteoglycans (Proteoglycan)IBA 01/2019 - 12/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2018 - 12/2007
3	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 04/2004
2	tofacitinibIBA 01/2022 - 08/2014
2	EnzymesIBA 01/2022 - 02/2014
2	2- (5- benzo(1,3)dioxol- 5- yl- 2- tert- butyl- 3H- imidazol- 4- yl)- 6- methylpyridine hydrochlorideIBA 01/2022 - 01/2022
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 09/2020
2	Phosphotransferases (Kinase)IBA 01/2022 - 05/2014
2	LuciferasesIBA 01/2022 - 01/2018
2	Toll-Like Receptor 4IBA 01/2020 - 01/2017
2	Collagenases (Collagenase)FDA Link 01/2019 - 01/2018
2	OligosaccharidesIBA 01/2019 - 01/2019
2	Interleukin-17 (Interleukin 17)IBA 12/2018 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 08/2018 - 10/2016
2	c-Mer Tyrosine KinaseIBA 01/2018 - 01/2018
2	AntibodiesIBA 01/2018 - 01/2017
2	LigandsIBA 01/2018 - 01/2018
2	Anti-Bacterial Agents (Antibiotics)IBA 11/2017 - 01/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2016 - 03/2007
2	Aggrecans (Aggrecan)IBA 01/2012 - 01/2007
2	ZymosanIBA 06/2009 - 12/2007
1	Tyrosine Kinase InhibitorsIBA 01/2022
1	Biological ProductsIBA 01/2022
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 11/2021
1	Liposomes (Liposome)IBA 11/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021
1	NADPH Oxidase 2IBA 10/2021
1	Pentetic Acid (DTPA)FDA LinkGeneric 12/2020
1	Etanercept (Enbrel)FDA Link 01/2020
1	ApolipoproteinsIBA 11/2019
1	Apolipoproteins E (ApoE)IBA 11/2019
1	Antigen-Antibody Complex (Immune Complex)IBA 11/2019
1	PrebioticsIBA 01/2019
1	5S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acidIBA 01/2019
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2019
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2018
1	InterferonsIBA 12/2018
1	GlucocorticoidsIBA 08/2018
1	Methylprednisolone FDA LinkGeneric 08/2018
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2018
1	Rheumatoid FactorIBA 01/2018
1	Immunoglobulin M (IgM)IBA 01/2018
1	Therapeutic UsesIBA 01/2018
1	Tartrate-Resistant Acid PhosphataseIBA 01/2018
1	CollagenIBA 11/2017
1	interleukin-21 (interleukin 21)IBA 01/2017
1	Tobramycin (Nebcin)FDA LinkGeneric 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	LipopolysaccharidesIBA 12/2016
1	Firefly LuciferasesIBA 12/2016
1	S100 Proteins (S 100 Protein)IBA 10/2016
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 10/2016
1	AutoantibodiesIBA 10/2016
1	Interleukin-10 (Interleukin 10)IBA 03/2016
1	LDL CholesterolIBA 01/2016
1	Drinking WaterIBA 09/2015
1	AdipokinesIBA 04/2015
1	Janus Kinase InhibitorsIBA 08/2014
1	Activins (Activin)IBA 05/2014

Therapy/Procedure

6	Therapeutics 01/2018 - 01/2010
4	Photochemotherapy (Photodynamic Therapy) 01/2022 - 12/2020
2	Intra-Articular Injections 01/2021 - 01/2018
1	Treatment Delay 09/2015
1	Oral Administration 09/2015